Spray the inside of a loaf pan with cooking spray and set aside.
Whisk flour, baking powder and salt together in a medium bowl. Set aside.
Combine sugar, butter and lemon zest in a large mixing bowl. Beat for about 2 minutes. Scrape down sides of bowl and add eggs, one at a time, beating after each addition.
Add the lemon juice and vanilla and mix well.
Reduce mixing speed to low and add dry ingredients in 3 additions, alternating with buttermilk in two additions, beginning and ending with dry ingredients.
Pour into prepared pan and bake for 45-50 minutes or until toothpick inserted in the center of the cake comes out clean.
Place the pan on a cooling rack and cool, about 30 minutes.
Carefully invert cake onto rack; remove pan and let cake cool completely.